Lipid rescue of massive verapamil overdose: a case report
2011
Lipid Rescue for Verapamil Overdose
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Liang Conrad W, Diamond Sarah J, Hagg Daniel S
Primary Institution: Oregon Health and Science University
Hypothesis
Can intravenous lipid therapy effectively treat massive verapamil overdose?
Conclusion
Intravenous fat emulsion therapy may be an effective antidote for massive verapamil toxicity.
Supporting Evidence
- The patient ingested 19.2 g of verapamil and required multiple treatments before lipid therapy was initiated.
- Lipid therapy led to a significant reduction in vasopressor requirements within hours.
- The patient regained a stable heart rhythm and improved hemodynamics after lipid infusion.
Takeaway
If someone takes too much verapamil, a type of heart medicine, giving them fat through an IV can help them get better.
Methodology
The patient was treated with various therapies including intravenous lipid infusion after standard treatments failed.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
41-year-old Caucasian woman with a history of depression.
Digital Object Identifier (DOI)
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