Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
2003
Comparing Age-of-Onset and Systolic Blood Pressure in Hypertension Analysis
publication
Evidence: moderate
Author Information
Author(s): Daw E Warwick, Liu Xiaoming, Wu Chih-Chieh
Primary Institution: University of Texas MD Anderson Cancer Center
Hypothesis
Does the choice of measure for hypertension affect the identification of trait-related genes?
Conclusion
Different measures of hypertension can identify different trait-related genes.
Supporting Evidence
- Age-of-onset analysis was better at identifying 'slope' genes.
- Systolic blood pressure analysis was better at identifying 'baseline' genes.
- Linkage signals found for only one measure can represent a true trait locus.
Takeaway
This study looked at two ways to measure hypertension and found that each way can point to different genes that affect the condition.
Methodology
Monte Carlo Markov chain analysis was used to compare age-of-onset of hypertension and systolic blood pressure in genetic linkage analysis.
Limitations
The study used simulated data, which may not fully represent real-world complexities.
Digital Object Identifier (DOI)
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