MRI-Based Atlas of the Developing Mouse Brain
Author Information
Author(s): David C. Holzman
Primary Institution: Johns Hopkins University
Hypothesis
The new MRI-based atlas provides a baseline for studying how pollutants and genetic mutations affect brain development in mouse models.
Conclusion
The MRI-based atlas significantly reduces the time and effort needed to analyze brain development in mice.
Supporting Evidence
- The atlas provides a baseline for studies of how pollutants and genetic mutations affect brain development.
- It quantifies the whole brain and its substructures, mapping white matter tracts and gray matter structures.
- The atlas is expected to have applications comparable to polymerase chain reaction in environmental toxicology.
Takeaway
Scientists created a new map of mouse brains that helps them understand how things like pollution can change brain development, and it makes their work much easier.
Methodology
The atlas uses three-dimensional microimaging with MRI to capture the anatomy of the entire mouse brain from embryonic day 12 to postnatal day 80.
Limitations
The atlas may not cover all developmental stages comprehensively.
Participant Demographics
The atlas quantifies the brain of the widely used C57BL/6 mouse.
Want to read the original?
Access the complete publication on the publisher's website