Efficacy of Nebulized Beclomethasone in Young Children with Wheezing
Author Information
Author(s): Papi Alberto, Nicolini Gabriele, Boner Attilio L, Baraldi Eugenio, Cutrera Renato, Fabbri Leonardo M, Rossi Giovanni A
Primary Institution: University of Ferrara
Hypothesis
Is nebulized beclomethasone more effective than placebo in treating wheezing episodes in preschool children?
Conclusion
Nebulized beclomethasone is effective in increasing symptom-free days and improving cough in preschool children with wheezing.
Supporting Evidence
- The BDP group had a higher percentage of symptom-free days (54.7%) compared to the placebo group (40.5%).
- Cough scores were significantly lower in the BDP group (0.11) than in the placebo group (0.39).
- The positive effects of BDP treatment were similar in children with and without risk factors for asthma.
Takeaway
This study shows that a week of treatment with a medicine called beclomethasone helps young kids with wheezing feel better and have more days without symptoms.
Methodology
A post-hoc analysis comparing nebulized beclomethasone with placebo in preschool children during an acute wheezing episode.
Limitations
The analysis was based only on the first week of a longer clinical trial and P-values were unadjusted for multiplicity.
Participant Demographics
Participants were preschool children aged 1-4 years, with a history of recurrent wheezing.
Statistical Information
P-Value
0.012
Confidence Interval
95% CI: 1.08, 6.51
Statistical Significance
p = 0.012
Digital Object Identifier (DOI)
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