Homolmapper: A Tool for Mapping Protein Homology onto Structure
Author Information
Author(s): Rockwell Nathan C, Lagarias J Clark
Primary Institution: University of California, Davis
Hypothesis
Homolmapper aims to provide a flexible command-line tool for mapping homology information from protein sequence alignments onto protein structures.
Conclusion
Homolmapper is a useful tool for analyzing homology relationships among proteins in a structural context.
Supporting Evidence
- Homolmapper is small and portable, written in Python.
- It allows for the incorporation of additional scoring schemes and non-canonical residues.
- Extensive documentation is available to assist users.
Takeaway
Homolmapper helps scientists see how similar proteins are by showing their structures and relationships, making it easier to study them.
Methodology
Homolmapper is a command-line application that maps information from multiple protein sequence alignments onto protein structures, allowing for user-defined scoring schemes and handling of non-canonical residues.
Limitations
Homolmapper's outputs must conform to the PDB standard, which imposes limitations on the nature of the outputs.
Digital Object Identifier (DOI)
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