Oophorectomy and Pancreatic Cancer in Hamsters
Author Information
Author(s): J.F. Chester, R.I. Nicholson, J.V. Lever, A.R. Turnbull, D.C. Britton
Primary Institution: Royal United Hospital and University of Wales College of Medicine
Hypothesis
Does oophorectomy affect pancreatic carcinogenesis in Syrian hamsters?
Conclusion
Oophorectomy had no significant effect on the incidence of pancreatic cancer in Syrian hamsters.
Supporting Evidence
- All animals gained weight equally following surgery.
- 95% of the hamsters survived to the end of the experiment.
- There was no difference in the incidence of pancreatic cancer between the oophorectomy and control groups.
Takeaway
Removing the ovaries didn't change how many hamsters got pancreatic cancer in this study.
Methodology
Female Syrian hamsters were divided into two groups, one undergoing oophorectomy and the other a sham operation, followed by injections of a carcinogen.
Limitations
The study did not assess the contribution of the adrenals to estrogen production or changes in estrogen receptor status.
Participant Demographics
Female Syrian hamsters, aged 5 weeks.
Want to read the original?
Access the complete publication on the publisher's website