Antibiotic Resistance Patterns in Group B Streptococcus
Author Information
Author(s): Lubna Chohan, Lisa M. Hollier, Karen Kilpatrick, Charles C.
Primary Institution: University of Texas Medical School at Houston
Hypothesis
What are the prevalence and antibiotic resistance patterns of group B streptococcus among pregnant women?
Conclusion
Group B Streptococcus was found in 12.2% of swabs, with common resistance to certain antibiotics but no significant increase in resistance over time.
Supporting Evidence
- 154 out of 1264 swabs tested positive for GBS.
- Resistance to ampicillin was not found in any isolates.
- Resistance to erythromycin was found in 10% of isolates in 2002 and 9% in 2004.
- Resistance to clindamycin was found in 10% of isolates in 2002 and 13% in 2004.
- Resistance to cefazolin was found in 2% of isolates in 2002 and 4% in 2004.
- Resistance prevalence was higher among Caucasian women compared to African-American and Hispanic women.
Takeaway
This study looked at pregnant women to see how many had a germ called group B Streptococcus and if that germ was resistant to common antibiotics. They found some resistance but not a lot of change over the years.
Methodology
Pregnant women presenting to triage at two hospitals were screened for GBS using swabs and tested for antibiotic resistance.
Potential Biases
Potential bias due to the demographic characteristics of the sample and antibiotic use reporting.
Limitations
The study did not perform repeat surveillance cultures and had small sample sizes for some comparisons.
Participant Demographics
The majority of participants were Hispanic (75%), followed by African-American (18%) and Caucasian (6%).
Statistical Information
P-Value
.41
Confidence Interval
95% CI 1.2, 2.9
Statistical Significance
p = .41
Digital Object Identifier (DOI)
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