Endostatin Gene Variation and Breast Cancer
Author Information
Author(s): Balasubramanian Sabapathy P, Cross Simon S, Globe Jenny, Cox Angela, Brown Nicola J, Reed Malcolm W
Primary Institution: University of Sheffield
Hypothesis
The study aimed to determine the role of the Endostatin polymorphism in breast cancer pathogenesis and its influence on serum Endostatin levels.
Conclusion
The Endostatin 4349A allele is associated with invasive breast cancer, but not with breast cancer susceptibility or severity.
Supporting Evidence
- The rare allele (A) was significantly associated with invasive breast cancers compared to non-invasive tumors.
- There was no association with breast cancer susceptibility.
- Serum Endostatin levels were not associated with genotype.
- Endostatin protein expression showed no significant correlation with tumor characteristics.
Takeaway
This study looked at a gene related to a protein that helps stop tumors from growing. They found that a specific change in this gene is linked to more serious breast cancer but not to getting breast cancer in the first place.
Methodology
The study involved genotyping the Endostatin polymorphism in breast cancer cases and controls, measuring serum Endostatin levels, and assessing protein expression on tissue microarrays.
Potential Biases
Potential bias due to the restriction of the study population to a single ethnic group.
Limitations
The study was limited to Caucasian women and did not perform multivariate analyses due to its exploratory nature.
Participant Demographics
Caucasian women, including 846 breast cancer cases and 707 controls.
Statistical Information
P-Value
0.03
Confidence Interval
95% CI = 1–17.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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