Morphometric grading of breast cancer: thresholds for tubular differentiation
2000
Grading Breast Cancer by Tubular Differentiation
Sample size: 172
publication
Evidence: moderate
Author Information
Author(s): Kronqvist P, Kuopio T, Collan Y
Primary Institution: Department of Pathology, University of Turku
Hypothesis
What are the numerical thresholds for histological breast cancer grading based on tubular differentiation?
Conclusion
Tubular differentiation observed in at least 60% of tumor fields indicates a favorable prognosis for breast cancer.
Supporting Evidence
- Patients with tubular differentiation below 59% have a 6.7-fold increased risk of breast cancer death.
- Patients with tubular differentiation above 59% have a 6.3-fold increased risk of breast cancer death.
Takeaway
If a lot of the cancer looks like tubes under the microscope, it’s a good sign for the patient.
Methodology
The study evaluated tubular differentiation in breast cancer samples using survival analysis and regression methods.
Statistical Information
P-Value
59%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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