REVERSING INSULIN RESISTANCE AND SARCOPENIA BY LOWERING TOXIC CERAMIDES IN OBESE NONHUMAN PRIMATES
2024
Lowering Toxic Ceramides to Reverse Insulin Resistance in Obese Primates
publication
Author Information
Author(s): Palavicini Juan, Murton Andrew
Primary Institution: UT Health SA, San Antonio, Texas, United States; UTMB Health, Galveston, Texas, United States
Hypothesis
Ceramides are major drivers of insulin resistance and frailty.
Conclusion
Myriocin, an inhibitor of ceramide synthesis, restores insulin resistance in obese and diabetic mice.
Supporting Evidence
- Older obese men have a diminished capacity to synthesize new muscle proteins.
- Ceramides accumulate in insulin sensitive organs, including muscle.
- Myriocin restores insulin resistance in obese and diabetic mice.
Takeaway
This study is looking at how a substance called myriocin can help older, obese monkeys who have trouble using insulin and building muscle.
Methodology
Lipidomics approaches combined with mouse models of obesity and diabetes were used, along with a pilot study in non-human primates.
Participant Demographics
Obese and old nonhuman primates, specifically marmosets.
Digital Object Identifier (DOI)
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