Sex differences in psychiatric comorbidities of attention-deficit/hyperactivity disorder among children, adolescents, and adults: A nationwide population-based cohort study
2025

Sex Differences in Psychiatric Comorbidities of ADHD

Sample size: 112225 publication 10 minutes Evidence: high

Author Information

Author(s): Kao Pei-Hsin, Ho Chung-Han, Huang Charles Lung-Cheng

Primary Institution: Chi Mei Medical Center, Tainan, Taiwan

Hypothesis

This study aims to elucidate sex differences in psychiatric comorbidities of Attention-deficit/hyperactivity disorder (ADHD) across different age groups.

Conclusion

The study found distinct sex-based patterns in psychiatric comorbidities associated with ADHD, with males showing higher rates of certain disorders in childhood and females exhibiting increased vulnerability to emotional disorders in adulthood.

Supporting Evidence

  • ADHD was significantly more prevalent among males under the age of 18.
  • Females exhibited higher rates of emotional disorders in adulthood.
  • The prevalence of learning disabilities and tics decreased with age.
  • Anxiety and depressive disorders increased with age, particularly in adults.
  • Adult males with ADHD faced a more pronounced burden of comorbidities.

Takeaway

Boys with ADHD often have learning problems, while girls with ADHD are more likely to have emotional issues as they grow up.

Methodology

This cross-sectional study analyzed data from Taiwan’s National Health Insurance Research Database, focusing on individuals diagnosed with ADHD and their psychiatric comorbidities across different age groups.

Potential Biases

Potential underdiagnosis of ADHD in females and reliance on database records may introduce inaccuracies.

Limitations

The study may over-represent more severe cases of ADHD due to its diagnostic criteria requiring multiple outpatient visits or hospitalization.

Participant Demographics

The cohort consisted of 112,225 individuals diagnosed with ADHD, with 78.02% males and 21.98% females, categorized into three age groups: 0–12 years, 13–18 years, and ≥18 years.

Statistical Information

P-Value

<0.0001

Confidence Interval

95% C.I.

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0315587

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