Atovaquone/Proguanil Effectiveness Against Malaria in Thailand
Author Information
Author(s): Khositnithikul Rommanee, Tan-ariya Peerapan, Mungthin Mathirut
Primary Institution: Mahidol University
Hypothesis
What is the in vitro susceptibility of Plasmodium falciparum to atovaquone/proguanil in Thai isolates?
Conclusion
Atovaquone/proguanil is effective for treating multidrug-resistant falciparum malaria in Thailand.
Supporting Evidence
- All 83 Thai isolates were sensitive to atovaquone.
- None of the isolates contained mutations at codon 268 of the cytb gene.
- The mean atovaquone IC50 was 3.4 nM, indicating sensitivity.
Takeaway
This study found that a malaria treatment called atovaquone/proguanil works well against malaria in Thailand, even in tough cases.
Methodology
Eighty-three P. falciparum isolates were tested for drug susceptibility using radioisotopic assays and mutations were analyzed by PCR-RFLP and sequencing.
Limitations
The study only included isolates from specific regions and years, which may not represent all cases.
Participant Demographics
Isolates collected from four endemic areas along the Thai-Myanmar and Thai-Cambodia borders.
Statistical Information
P-Value
0.021
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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