Impact of Small Body Weight on Tenofovir-Associated Renal Dysfunction in HIV-Infected Patients
Author Information
Author(s): Nishijima Takeshi, Komatsu Hirokazu, Gatanaga Hiroyuki, Aoki Takahiro, Watanabe Koji, Kinai Ei, Honda Haruhito, Tanuma Junko, Yazaki Hirohisa, Tsukada Kunihisa, Honda Miwako, Teruya Katsuji, Kikuchi Yoshimi, Oka Shinichi
Primary Institution: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan
Hypothesis
Does small body weight increase the risk of tenofovir-associated renal dysfunction in HIV-infected patients?
Conclusion
Small body weight is an independent risk factor for tenofovir-associated renal dysfunction in Japanese patients.
Supporting Evidence
- 19.6% of patients experienced tenofovir-related renal dysfunction.
- Tenofovir-related renal dysfunction occurred at an incidence of 10.5 per 100 person-years.
- Smaller body weight was significantly associated with renal dysfunction.
- Older age and concurrent smoking were also identified as risk factors.
- Patients with a median weight of 63 kg were analyzed.
Takeaway
If you're small and take a medicine called tenofovir for HIV, you might need to be extra careful because it can hurt your kidneys.
Methodology
Retrospective cohort study analyzing Japanese HIV-infected patients on tenofovir therapy.
Potential Biases
Selection bias may have led to an underestimation of the incidence of renal dysfunction.
Limitations
The study is retrospective and lacks a control group for comparison.
Participant Demographics
Median age 38 years, 95.2% male, median weight 63 kg.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 1.01–1.27
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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