Chitosan-Based Microspheres for Ambroxol Hydrochloride
Author Information
Author(s): Gangurde HH, Chavan NV, Mundada AS, Derle DV, Tamizharasi S
Primary Institution: SNJB’s Shriman Suresh Dada Jain College of Pharmacy
Hypothesis
The study investigates how different cross-linking methods affect the properties of ambroxol hydrochloride microspheres.
Conclusion
Heat-treated chitosan microspheres showed better performance than those cross-linked with formaldehyde, despite the latter having higher encapsulation efficiency.
Supporting Evidence
- Heat-treated microspheres were spherical and had a smooth, porous structure.
- Encapsulation efficiency ranged from 39.73% to 80.56% depending on the cross-linking method.
- Drug release from the microspheres was sustained for up to 12 hours.
Takeaway
The study looked at how to make tiny balls of medicine that can release a cough medicine slowly, and found that using heat is better than using a chemical that can be harmful.
Methodology
Chitosan microspheres were prepared using solvent evaporation and characterized by various techniques including SEM, XRD, DSC, and FTIR.
Limitations
The use of formaldehyde as a cross-linking agent poses toxicity risks and challenges in ensuring its complete removal from the microspheres.
Digital Object Identifier (DOI)
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