Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models
2011
Wound Healing Potential of Achillea biebersteinii
Sample size: 6
publication
Evidence: high
Author Information
Author(s): Esra Küpeli Akkol, Koca Ufuk, Pesin Ipek, Yilmazer Demet
Primary Institution: Gazi University
Hypothesis
The study aims to investigate the in vivo wound healing activity of Achillea biebersteinii.
Conclusion
The n-hexane extract of Achillea biebersteinii showed significant wound healing activity comparable to the reference drug Madecassol.
Supporting Evidence
- The n-hexane extract treated groups showed 84.2% contraction in wound area.
- The tensile strength of the n-hexane extract treated group increased by 40.1% compared to other groups.
- Histopathological examination showed collagen formation and mature hair follicles in the n-hexane extract treated group.
Takeaway
This study found that a plant called Achillea biebersteinii can help heal wounds, just like a common medicine.
Methodology
The study used in vivo circular excision and linear incision wound models on mice and rats to evaluate the wound healing activity of different extracts of the plant.
Participant Demographics
Male, Sprague-Dawley rats and Swiss albino mice.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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