Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs
2024
Effects of NSAIDs on Tryptophan Levels
publication
Author Information
Author(s): FitzGerald Garret
Hypothesis
How do naproxen and celecoxib affect tryptophan and kynurenine levels in humans?
Conclusion
Naproxen decreases tryptophan and kynurenine levels in plasma, independent of Cox-1 and Cox-2 inhibition.
Supporting Evidence
- Naproxen treatment led to decreased levels of tryptophan and kynurenine in human plasma.
- The decrease in tryptophan was due to naproxen displacing bound tryptophan.
- Supplementation of tryptophan in treated mice improved health outcomes.
Takeaway
Naproxen, a common pain reliever, can lower certain important substances in the body, which might affect health.
Methodology
The study compared the effects of naproxen and celecoxib on plasma levels in humans and validated findings in mice.
Digital Object Identifier (DOI)
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