Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(Ii) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines.
2002
Synthesis and Testing of a New Platinum Compound for Cancer Treatment
publication
Evidence: low
Author Information
Author(s): Robert I. Haines, Aleisha M. Murnaghan
Primary Institution: University of Prince Edward Island
Hypothesis
Does cis-dichloro-(1,4,7-triazacyclononane) platinum(II) have anti-cancer activity against human ovarian and leukemia cell lines?
Conclusion
The new platinum compound shows some cytotoxicity against ovarian cancer cells but is less effective than cisplatin.
Supporting Evidence
- The compound showed no activity against K-562 leukemia cells.
- Some cytotoxicity was observed against SK-OV-3 ovarian cancer cells.
- The compound is much less effective than cisplatin.
- Its limited solubility restricts the useable concentration range.
Takeaway
Researchers made a new platinum compound and tested it on cancer cells. It worked a little on ovarian cancer cells but not on leukemia cells.
Methodology
The compound was synthesized and tested on K-562 and SK-OV-3 cancer cell lines using MTT viability assays.
Limitations
The compound showed limited solubility, which restricted the concentration range for testing.
Want to read the original?
Access the complete publication on the publisher's website