CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells
2011
CXCL9 and Melanoma Metastasis
publication
Evidence: high
Author Information
Author(s): Amatschek S, Lucas R, Eger A, Pflueger M, Hundsberger H, Knoll C, Grosse-Kracht S, Schuett W, Koszik F, Maurer D, Wiesner C
Primary Institution: Medical University of Vienna
Hypothesis
Does CXCL9 increase melanoma metastasis?
Conclusion
CXCL9 promotes melanoma cell migration and disrupts endothelial barriers, facilitating metastasis.
Supporting Evidence
- CXCL9 is secreted by tumor endothelial cells in melanoma metastases.
- Low concentrations of CXCL9 attract melanoma cells, while high concentrations repel them.
- CXCL9 enhances the migration of melanoma cells through endothelial barriers.
Takeaway
CXCL9 is a chemical that helps melanoma cells move and escape from tumors, making it easier for them to spread.
Methodology
Melanoma cells were isolated and migration assays were performed to study their response to CXCL9.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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