Intestinal Colonization of Multidrug-Resistant Organisms in Healthy Individuals
Author Information
Author(s): Muacevic Alexander, Adler John R, Waddepally Vishnu Vandana, Rabye Sofiya, Bashir Ryhana, Kandi Venkataramana
Primary Institution: Vydehi Institute of Medical Sciences and Research Center
Hypothesis
What is the prevalence of multidrug-resistant bacteria in the intestines of healthy individuals in South India?
Conclusion
The study revealed a high carriage rate of multidrug-resistant organisms in the intestines of healthy adults in the community.
Supporting Evidence
- 57.04% of the isolated bacteria were confirmed as multidrug-resistant organisms.
- Klebsiella was the most resistant bacterial isolate among the tested organisms.
- High prevalence rates of ESBL and AmpC β-lactamase producers were observed.
Takeaway
This study found that many healthy people carry germs that are hard to treat with antibiotics, which can be a problem for everyone.
Methodology
A prospective study was conducted over six months, collecting and analyzing 255 fecal samples from healthy individuals for the presence of multidrug-resistant bacteria.
Potential Biases
Recall bias may affect the accuracy of self-reported data on prior antibiotic usage.
Limitations
The study mainly used conventional culture-based methods, which may have lower sensitivity compared to molecular techniques, and relied on self-reported data that could be affected by recall bias.
Participant Demographics
Participants were healthy adults aged 15 to 55, with a majority being male and educated.
Digital Object Identifier (DOI)
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