Synthesis, Characterization and Antitumour Activity of DI-n-Butyl and Dimethyltin Salicyloxhmates
1998
Antitumour Activity of Di-n-Butyltin Salicyloxamate
Sample size: 7
publication
Evidence: moderate
Author Information
Author(s): Marcel Gielen, Hassan Dalil, Dick de Vos, Monique Biesemans, Rudolph Willem
Primary Institution: Vrije Universiteit Brussel
Hypothesis
The study investigates whether the phenolic hydroxy group of salicyloxamic acid is involved in the reaction with diorganotin oxides.
Conclusion
Compound 1 shows higher antitumour activity than several clinically used drugs against certain human tumour cell lines.
Supporting Evidence
- Compound 1 is more active than cisplatin, 5-fluorouracil, and etoposide against seven tumoural cell lines.
- Compound 1 has a markedly higher in vitro activity than di-n-butyltin disalicylate and bis(acetylsalicylate).
- Compound 1's activity is lower than that of methotrexate and doxorubicin, except for H-226.
Takeaway
The researchers made a new compound that fights cancer better than some common treatments.
Methodology
The compounds were synthesized and tested against seven human tumour cell lines in vitro.
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