[(1R,3S)-6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 2.33-hydrate
2011
Structure of a New Tetrahydroisoquinoline Compound
publication
Evidence: moderate
Author Information
Author(s): Chakka Sai Kumar, McKay Michael G., Govender Thavendran, Kruger Hendrik G., Maguire Glenn E. M.
Primary Institution: University of KwaZulu-Natal
Conclusion
The study successfully synthesized a new tetrahydroisoquinoline compound and characterized its crystal structure.
Supporting Evidence
- The compound is the fourth in a series of similar tetrahydroisoquinoline derivatives.
- The N-heterocycle adopts a half-chair conformation.
- The study involved detailed crystallographic analysis using X-ray diffraction.
Takeaway
Scientists made a new chemical compound and looked at its structure to understand how it works.
Methodology
The compound was synthesized using a reaction involving amino ester and lithium aluminum hydride, followed by purification and crystallization.
Limitations
The hydrogen atoms of the water molecules in the crystal could not be located.
Digital Object Identifier (DOI)
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