Prognostic Role of Transforming Growth Factor Alpha in Lung Adenocarcinoma
Author Information
Author(s): M. Tateishi, T. Ishida, T. Mitsudomi, K. Sugimachi
Primary Institution: Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Hypothesis
Can transforming growth factor alpha (TGFa) serve as a prognostic parameter in adenocarcinoma of the lung?
Conclusion
High levels of TGFa in lung adenocarcinoma are associated with lower 5-year survival rates.
Supporting Evidence
- 92 patients had high TGFa levels, while 46 had low levels.
- The 5-year survival rate for patients with high TGFa was 39%, compared to 64% for those with low TGFa.
- Statistical analysis showed significant differences in survival rates based on TGFa levels.
Takeaway
This study found that patients with high levels of a protein called TGFa in their lung cancer cells had a lower chance of surviving for five years compared to those with low levels.
Methodology
The study used immunohistochemical staining on paraffin-embedded lung tissue samples from 138 patients to assess TGFa levels.
Limitations
The study excluded patients who died within the first post-operative month or underwent exploratory thoracotomy.
Participant Demographics
The cohort included 83 men and 55 women, aged 39 to 81 years, with varying stages of adenocarcinoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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