Cytotoxic T lymphocytes that recognize decameric peptide sequences of retinoblastoma binding protein 1 (RBP-1) associated with human breast cancer
1999
T-cells Targeting RBP-1 Peptides in Breast Cancer
Sample size: 41
publication
Evidence: moderate
Author Information
Author(s): Takahashi T, Cao J, Hoon D S B, Irie R F
Primary Institution: John Wayne Cancer Institute
Hypothesis
Can T-cells stimulated with RBP-1 decameric peptides kill human breast cancer cells?
Conclusion
The study found that T-cells stimulated with specific RBP-1 peptides can effectively kill breast cancer cells.
Supporting Evidence
- RBP-1 contains a peptide recognized by human antibodies and is overexpressed in breast cancer cells.
- T-cells stimulated with RBP-1 peptides showed specific cytotoxicity against breast cancer cells.
- No cytotoxicity was observed in T-cells from donors lacking HLA-A2 or HLA-A3.
Takeaway
Scientists found a way to make immune cells attack breast cancer by using special pieces of a protein called RBP-1.
Methodology
Peripheral blood lymphocytes from normal donors were stimulated with RBP-1 peptides and assessed for cytotoxic activity against breast cancer cells.
Participant Demographics
41 normal donors
Digital Object Identifier (DOI)
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