HGF Gene and Primary Angle Closure Glaucoma in Nepalese
Author Information
Author(s): Awadalla Mona S., Thapa Suman S., Burdon Kathryn P., Hewitt Alex W., Craig Jamie E.
Primary Institution: Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
Hypothesis
This study aimed to investigate whether genetic variation in HGF is associated with primary angle closure glaucoma in the Nepalese population.
Conclusion
Genetic variation in HGF is associated with PACG in the Nepalese population.
Supporting Evidence
- Four HGF SNPs were significantly associated with PACG.
- The study included 310 Nepalese individuals.
- The haplotype GAATGCCAG was significantly associated with PACG.
Takeaway
This study found that certain genes related to HGF might increase the risk of a type of glaucoma in people from Nepal.
Methodology
106 patients with primary angle closure glaucoma and 204 matched controls were genotyped for 12 SNPs.
Limitations
The use of CHB to tag the Nepalese samples may not fully represent the population.
Participant Demographics
Participants were 106 PACG cases and 204 controls, matched for sex and age, primarily from Nepal.
Statistical Information
P-Value
p=0.0006
Statistical Significance
p<0.05
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