Role of Proteinase-Activated Receptor-2 in Inflammation of Atlantic Salmon
Author Information
Author(s): Jim Thorsen, Einar Lilleeng, Elin Christine Valen, Åshild Krogdahl
Primary Institution: Norwegian School of Veterinary Science, Oslo, Norway
Hypothesis
Does PAR-2 play a role in soybean meal induced enteritis in Atlantic salmon?
Conclusion
The study suggests that PAR-2 may be involved in inflammatory responses in the intestine of Atlantic salmon fed soybean meal.
Supporting Evidence
- PAR-2 transcripts were detected in all 18 tissues examined, with high expression in the intestine and gills.
- Significant up-regulation of PAR-2a was observed after 1 day of feeding diets containing soybean meal.
- After 3 weeks of feeding, PAR-2a was down-regulated compared to control diets.
- PAR-2b showed significant up-regulation after 3 weeks, suggesting a role in chronic stages of enteritis.
Takeaway
This study looked at how a protein called PAR-2 might cause stomach problems in salmon that eat soybean meal. It found that this protein changes a lot when the salmon eat this type of food.
Methodology
The study involved cloning and characterizing the PAR-2 transcripts and analyzing their expression in various tissues of Atlantic salmon fed different diets.
Limitations
The study primarily focused on the expression of PAR-2 without exploring the full range of immune responses or the long-term effects of soybean meal diets.
Participant Demographics
Farmed Atlantic salmon (Salmobreed strain), average weight 214 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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