DHEA Replacement Improves Insulin Sensitivity in Older Adults
Author Information
Author(s): Weiss Edward P., Villareal Dennis T., Fontana Luigi, Han Dong-Ho, Holloszy John O.
Primary Institution: Washington University School of Medicine
Hypothesis
Does DHEA replacement improve glucose tolerance in elderly individuals?
Conclusion
DHEA replacement for one year significantly improves insulin action and glucose tolerance in elderly individuals with abnormal glucose tolerance.
Supporting Evidence
- DHEA replacement improved glucose tolerance in participants with abnormal glucose tolerance.
- Participants on DHEA showed significant decreases in inflammatory cytokines IL-6 and TNFα.
- Body fat percentage decreased in men receiving DHEA compared to those on placebo.
Takeaway
Taking DHEA can help older people use sugar better and lower inflammation in their bodies.
Methodology
Participants aged 65-75 were randomized to receive either DHEA or placebo for 12 months, followed by an open-label extension.
Potential Biases
Potential bias due to self-reported data and the open-label design in the second year.
Limitations
The study only included participants with abnormal glucose tolerance, limiting generalizability.
Participant Demographics
57 men and 68 women aged 65 to 75 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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