TNFSF4 Gene Polymorphism and Myocardial Infarction Risk
Author Information
Author(s): Ria Massimiliano, Lagercrantz Jacob, Samnegård Ann, Boquist Susanna, Hamsten Anders, Eriksson Per
Primary Institution: Karolinska University Hospital Solna, Stockholm, Sweden
Hypothesis
Is there a genetic variant in the TNFSF4 gene that influences the risk of myocardial infarction in women?
Conclusion
The TNFSF4 rs45454293T-allele is associated with lower TNFSF4 expression and increased risk of myocardial infarction.
Supporting Evidence
- Genetic variants in TNFSF4 are associated with myocardial infarction in women.
- The rs45454293T-allele is linked to lower transcriptional activity.
- Functional studies showed that the T-allele decreases gene expression.
- Allele-specific binding of nuclear proteins was observed for the rs45454293 polymorphism.
Takeaway
A specific change in a gene related to inflammation can make some women more likely to have heart attacks.
Methodology
The study involved genotyping and functional analyses of TNFSF4 polymorphisms in patients with myocardial infarction and controls.
Potential Biases
Potential bias due to the specific demographic focus on women and the reliance on self-reported data.
Limitations
The study's findings may not be generalizable beyond the specific populations studied.
Participant Demographics
The study included 387 individuals with myocardial infarction before age 60 and 387 age- and sex-matched controls.
Statistical Information
P-Value
0.02
Confidence Interval
95% confidence interval (0.77–1.49)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website