Detecting Early Alzheimer's Disease in MCI Patients
Author Information
Author(s): Ana Pozueta, Eloy Rodríguez-Rodríguez, José Luis Vazquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Soraya González-Perez, José Berciano, Onofre Combarros
Primary Institution: University Hospital 'Marqués de Valdecilla'
Hypothesis
Can baseline clinical and neuropsychological variables predict progression from MCI to AD dementia?
Conclusion
The combination of MMSE and CVLT-LDTR can distinguish Pr-AD from S-MCI at baseline.
Supporting Evidence
- 54 out of 109 MCI patients progressed to dementia.
- Subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93%.
- Those scoring below both tests had a positive predictive value of 80.95%.
Takeaway
Doctors can use two simple tests to tell if someone with mild memory problems is likely to develop Alzheimer's disease.
Methodology
Patients underwent clinical and neuropsychological evaluations at baseline and every 6 months for two years.
Potential Biases
Potential bias in patient selection and follow-up.
Limitations
The study excluded patients with other identifiable causes of cognitive impairment.
Participant Demographics
115 patients, 63.3% females, mean age 74.4 years.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI = 0.674-0.873
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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