Understanding Filovirus Infection and Cell Fate
Author Information
Author(s): Olejnik Judith, Ryabchikova Elena, Corley Ronald B., Mühlberger Elke
Primary Institution: Department of Microbiology, School of Medicine, Boston University
Hypothesis
What are the intracellular events leading to virus amplification and cell damage in filovirus infection?
Conclusion
Filoviruses exploit host cell mechanisms for replication, leading to significant cell damage and apoptosis, particularly in immune cells.
Supporting Evidence
- Filoviruses cause severe hemorrhagic fever with high fatality rates.
- Early target cells of filoviruses include monocytes, macrophages, and dendritic cells.
- Filovirus infection leads to the depletion of non-infected lymphocytes.
- Understanding the mechanisms of filovirus infection is crucial for developing effective treatments.
Takeaway
Filoviruses like Ebola and Marburg can make people very sick by infecting their immune cells and causing them to die, which makes it hard for the body to fight the virus.
Methodology
This review explores the mechanisms of filovirus infection, including how the viruses enter cells, replicate, and cause cell death.
Limitations
The review highlights gaps in understanding the complete mechanisms of filovirus pathogenesis and immune response.
Digital Object Identifier (DOI)
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