Effect of a cachectic factor on carbohydrate metabolism and attenuation by eicosapentaenoic acid
1999
Impact of a Cachectic Factor on Sugar Use and the Role of Eicosapentaenoic Acid
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Hussey H J, Tisdale M J
Primary Institution: Pharmaceutical Sciences Institute, Aston University
Hypothesis
How does a cachectic factor affect carbohydrate metabolism and can eicosapentaenoic acid mitigate this effect?
Conclusion
The study found that a cachectic factor significantly disrupts glucose utilization, but this effect can be reversed with eicosapentaenoic acid treatment.
Supporting Evidence
- Mice receiving the cachectic factor showed significant weight loss.
- Eicosapentaenoic acid treatment reversed the weight loss and hypoglycemia caused by the cachectic factor.
- The cachectic factor increased glucose utilization in some organs while decreasing it in others.
Takeaway
When certain tumors produce a factor that makes the body use sugar differently, giving a special fatty acid can help fix that problem.
Methodology
The study used the 2-deoxyglucose tracer technique to assess glucose utilization in mice.
Participant Demographics
Mice were used in the study.
Digital Object Identifier (DOI)
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