Controlled-Release Carbamazepine Tablets
Author Information
Author(s): Barakat Nahla S. Elbagory, Ibrahim M. Almurshedi, Alanood S.
Primary Institution: King Saud University
Hypothesis
The study investigates how lipophilic and hydrophilic components affect the release of carbamazepine from granules and tablets.
Conclusion
The combination of Compritol® with HPMC and Avicel can effectively sustain the release of carbamazepine over time.
Supporting Evidence
- Increasing HPMC concentration reduces the release rate of carbamazepine.
- The release mechanism shifts from diffusion to erosion with higher HPMC content.
- The study found that wet granulation is suitable for sustained release formulations.
Takeaway
This study shows that mixing certain ingredients can help medicine dissolve slowly in your body, which is better for some treatments.
Methodology
Wet granulation followed by compression was used to prepare the granules and tablets, and various dissolution tests were conducted.
Limitations
The study does not address long-term effects of the formulations in vivo.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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