MDR1 causes resistance to the antitumour drug miltefosine
2001
MDR1 Causes Resistance to Miltefosine in Cancer Cells
publication
Author Information
Author(s): Rybczynska M, Liu R, Lu P, Sharom F J, Steinfels E, Pietro A Di, Spitaler M, Grunicke H, Hofmann J
Primary Institution: Institute of Medical Chemistry and Biochemistry, University of Innsbruck
Hypothesis
Does the expression of MDR1 affect the sensitivity of cancer cells to miltefosine?
Conclusion
MDR1 expression reduces the sensitivity of cancer cells to miltefosine treatment.
Supporting Evidence
- Cells overexpressing MDR1 were less sensitive to miltefosine compared to sensitive parental cell lines.
- HeLa cells transfected with MDR1 exhibited resistance to miltefosine.
- Expression of MDR2 did not correlate with resistance to miltefosine.
- Miltefosine bound to P-glycoprotein with a Kd of approximately 7 μM.
Takeaway
Some cancer cells can become less responsive to a drug called miltefosine because they have a special gene called MDR1. This means the drug might not work as well in those cases.
Methodology
The study investigated the sensitivity of various cancer cell lines expressing MDR1 to miltefosine treatment.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website