Interleukin-10 Levels and Outcomes in Acute Coronary Syndrome
Author Information
Author(s): Mälarstig A, Eriksson P, Hamsten A, Lindahl B, Wallentin L, Siegbahn A
Primary Institution: Uppsala University
Hypothesis
What is the relationship between plasma interleukin-10 concentration at hospital admission and outcomes in patients with non-ST elevation acute coronary syndrome?
Conclusion
IL-10 reflects a proinflammatory state in patients with acute coronary syndrome and may be a useful biomarker for predicting future cardiovascular events.
Supporting Evidence
- IL-10 levels were significantly higher in patients than in healthy controls.
- The highest risk of death or myocardial infarction was observed in patients with the highest IL-10 levels.
- Adjustment for common risk indicators weakened the association between IL-10 and outcomes.
Takeaway
This study found that higher levels of a substance called interleukin-10 in the blood can mean a higher risk of serious heart problems for patients with chest pain.
Methodology
The study measured IL-10 plasma concentrations and genotyped SNPs in patients with acute coronary syndrome and healthy controls.
Limitations
The association between IL-10 levels and outcomes weakened after adjusting for other risk indicators.
Participant Demographics
Patients included 3179 individuals with non-ST elevation acute coronary syndrome and 393 healthy controls, matched for age and gender.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 1.2 to 2.3
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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