Cord Blood T Cell Responses to Self Heat Shock Protein 60
Author Information
Author(s): Aalberse Joost A., Kapitein Berber, de Roock Sytze, Klein Mark R., de Jager Wilco, van der Zee Ruurd, Hoekstra Maarten O., van Wijk Femke, Prakken Berent J.
Primary Institution: Wilhelmina Children's Hospital, Utrecht, The Netherlands
Hypothesis
Are self-HSP60 reactive T cells present in cord blood, and what phenotype do these cells have?
Conclusion
Self-reactive HSP60 specific T cells are already present at birth and may help regulate neonatal immune responses.
Supporting Evidence
- HSP60-induced T cells proliferate and produce cytokines like IL-10 and IFN-gamma.
- 50% of cord blood samples showed a clear proliferative response to HSP60.
- HSP60-induced T cells expressed FOXP3 and suppressed effector T cell responses in vitro.
- Significant increases in cytokines were observed after stimulation with HSP60 compared to controls.
Takeaway
The study found that babies are born with special immune cells that can recognize a protein called HSP60, which helps keep their immune system balanced.
Methodology
Cord blood mononuclear cells were cultured with HSP60 and Tetanus Toxoid to study T cell proliferation and cytokine production.
Limitations
The study did not collect detailed maternal or pregnancy information.
Participant Demographics
Healthy, full-term neonates.
Statistical Information
P-Value
p=0.038
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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