Antibacterial and Antifungal Activity of Zinc(II) Carboxylates
Author Information
Author(s): V. Zelenak, K. Györyová, D. Mlynarcik
Primary Institution: P. J. Šafárik University
Hypothesis
The study investigates the antibacterial and antifungal activity of zinc(II) carboxylates with and without N-donor organic ligands.
Conclusion
Zinc(II) carboxylates exhibit good antibacterial activity against Staphylococcus aureus but have negligible effects on Candida albicans.
Supporting Evidence
- Zinc(II) carboxylates showed the highest efficiency against Staphylococcus aureus.
- The antibacterial effect decreased with increasing carboxylate chain length.
- Substitution of hydrogen with halogens improved antibacterial activity.
- Nicotinamide and caffeine ligands did not enhance the efficiency of zinc(II) carboxylates.
Takeaway
This study looks at how certain zinc compounds can fight germs, especially one called Staphylococcus aureus, but not so much against yeast.
Methodology
The compounds were synthesized and tested for antibacterial activity against specific bacterial strains and yeast using minimum inhibitory concentration (MIC) methods.
Limitations
The study notes that low thermodynamic stability of the compounds may affect their biological activity.
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