European randomized study of prostate cancer screening: first-year results of the Finnish trial
1999
First-Year Results of Finnish Prostate Cancer Screening Trial
Sample size: 5053
publication
Evidence: moderate
Author Information
Author(s): Määttänen L, Auvinen A, Stenman U-H, Rannikko S, Tammela T, Aro J, Juusela H, Hakama M
Primary Institution: Finnish Cancer Registry
Hypothesis
Does prostate cancer screening improve detection rates in men aged 55-67?
Conclusion
The study found that prostate cancer screening detected a significant number of localized and potentially curable cancers.
Supporting Evidence
- The participation rate in the screening arm was 69%.
- 8.5% of screened participants had a PSA concentration of 4.0 ng/ml or higher.
- 106 cancers were detected, indicating a positive predictive value of 27%.
- 85% of screen-detected prostate cancers were localized.
Takeaway
The study showed that screening for prostate cancer can find cancers early, which might help men get better treatment.
Methodology
Men aged 55-67 were randomized into screening and control groups, with screening conducted using PSA tests.
Participant Demographics
Approximately 20,000 men aged 55-67 from two areas in Finland.
Digital Object Identifier (DOI)
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