Vasculogenic Mimicry in Gallbladder Carcinomas
Author Information
Author(s): Sun Wei, Fan Yue Z, Zhang Wen Z, Ge Chun Y
Primary Institution: Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Hypothesis
The two different tumor cell lines, GBC-SD and SGC-996, can exhibit significant different invasive ability and possess discrepancy of VM channels formation.
Conclusion
Vasculogenic mimicry exists in gallbladder carcinomas both in vitro and in vivo.
Supporting Evidence
- 85.7% of GBC-SD nude mouse xenografts showed evidence of vasculogenic mimicry.
- 5.7% of channels contained red blood cells among tumor cell-lined vasculatures.
- GBC-SD cells formed hollowed vasculogenic-like structures in three-dimensional cultures.
Takeaway
Some cancer cells can create their own blood supply without using normal blood vessels, which helps them grow and spread.
Methodology
The study used cell culture, invasion assays, and xenograft models in nude mice to investigate the invasive potential and vasculogenic mimicry of gallbladder carcinoma cell lines.
Limitations
Only two different established GBC cell lines were enrolled, limiting the comprehensiveness of the conclusions.
Statistical Information
P-Value
0.0013
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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