Stroke Phenotypes in Atrial Fibrillation Patients
Author Information
Author(s): Oh Semi, Kim Suk Jae, Ryu Soo-Kyoung, Kim Gyeong-Moon, Chung Chin Sang, Lee Kwang Ho, Bang Oh Young
Primary Institution: Samsung Medical Centre, Sungkyunkwan University, South Korea
Hypothesis
What factors, other than INR levels, affect stroke phenotypes in patients with atrial fibrillation who are not adequately anticoagulated?
Conclusion
The determinants of stroke phenotypes differ from the predictors of stroke in patients with atrial fibrillation.
Supporting Evidence
- Stroke phenotypes varied among 231 patients.
- The DWI lesion volumes ranged from 0.04-338.62 ml.
- CHADS2 and CHA2DS2-VASc scores were not related to stroke phenotypes.
- Congestive heart failure and diastolic dysfunction were not associated with stroke phenotypes.
Takeaway
This study found that the reasons for different types of strokes in patients with heart rhythm problems are not the same as the usual risk factors we think of.
Methodology
Data from consecutive atrial fibrillation patients with acute MCA territory infarcts were analyzed over a 6-year period, focusing on DWI lesion volumes and patterns.
Potential Biases
Potential bias due to the exclusion of patients with large artery disease and those not adequately anticoagulated.
Limitations
The study had a modest sample size and was conducted at a single center.
Participant Demographics
231 patients (118 men and 113 women; average age 70.0 years).
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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