6-Oxo-5-[(trifluoromethyl)sulfonyl]-1,2,4a,5,6,11b-hexahydro-1,3-dioxolo[4,5-j]phenanthridin-2-yl benzoate
2011
Unexpected Product from Phenanthridones Alkaloids Synthesis
publication
Evidence: moderate
Author Information
Author(s): Wu Chunli, Li Pan, Shi Xiufang, Pan Xiaotao, Wu Jizhou
Primary Institution: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
Hypothesis
The formation of the title compound is due to the overuse of Tf2O in the synthesis process.
Conclusion
The title compound exhibits potent inhibitory activity against various cancer cell lines.
Supporting Evidence
- The compound shows inhibitory activity against MCF-7 cells with an IC50 of 4.46 µg/ml.
- It also inhibits SK—N—SH cells with an IC50 of 1.89 µg/ml.
- The SPC-A-1 cells are inhibited with an IC50 of 1.35 µg/ml.
Takeaway
Scientists made a new chemical that can stop cancer cells from growing. They found it by changing how they made another chemical.
Methodology
The compound was synthesized using a modified Bischler-Napieralski reaction and characterized using X-ray crystallography.
Digital Object Identifier (DOI)
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