Genetic Variants at 1p11.2 and Breast Cancer Risk in Chinese Women
Author Information
Author(s): Jiang Yue, Shen Hao, Liu Xiao'an, Dai Juncheng, Jin Guangfu, Qin Zhenzhen, Chen Jiaping, Wang Shui, Wang Xinru, Hu Zhibin, Shen Hongbing
Primary Institution: Nanjing Medical University
Hypothesis
Are there genetic variants at 1p11.2 associated with breast cancer risk in Chinese women?
Conclusion
The study found that the SNP rs2580520 is associated with an increased risk of breast cancer in Chinese women, while rs11249433 showed no significant association.
Supporting Evidence
- The study included 1792 breast cancer cases and 1867 controls.
- SNP rs2580520 was significantly associated with breast cancer risk in a recessive genetic model.
- No significant association was found for SNP rs11249433 in the Chinese population.
Takeaway
Scientists looked at genes to see if they could find out why some Chinese women get breast cancer. They found one gene that seems to make it more likely.
Methodology
A two-stage fine-mapping study with 1792 breast cancer cases and 1867 controls was conducted, using SNP genotyping.
Limitations
The study had a relatively low power due to the limited sample size and low minor allele frequency of the rs11249433 SNP.
Participant Demographics
Participants were genetically unrelated ethnic Han Chinese women from Nanjing City and surrounding regions.
Statistical Information
P-Value
0.005
Confidence Interval
1.16–2.36
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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