Colorectal Cancer Genomics and Survival
Author Information
Author(s): Rooney P H, Boonsong A, McKay J A, Marsh S, Stevenson D A J, Murray G I, Curran S, Haites N E, Cassidy J, McLeod H L
Primary Institution: University of Aberdeen
Hypothesis
Differences in the genetic make-up of tumours may be partially responsible for the differences observed in survival among same staged individuals for colorectal cancer.
Conclusion
Patients with more than two genomic aberrations had better survival than those with fewer regions of loss and gain.
Supporting Evidence
- Great variation in genetic grade was observed in 29 Dukes' C colorectal tumours.
- 76% of tumours showed gain and 41% showed loss of genetic material.
- The most frequently observed regions of gain included 13q, 20q, and 7p.
- The most frequently observed regions of loss included 18q, 4q, and 17p.
- Patients with more than two aberrations had better survival than those with fewer regions of loss and gain.
Takeaway
This study looked at the genes in tumors from colorectal cancer patients and found that those with more genetic changes tended to live longer.
Methodology
The tumour genomes of 29 consecutive patients were assessed by comparative genomic hybridization (CGH).
Limitations
The study does not establish a direct association between specific genomic aberrations and patient survival.
Participant Demographics
Patients undergoing surgery for Dukes' C colorectal cancer.
Statistical Information
P-Value
0.02
Statistical Significance
p=0.02
Digital Object Identifier (DOI)
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