Field Change in Oral Cancer Based on Cytokeratin Expression
Author Information
Author(s): G.R. Ogden, E.B. Lane, D.V. Hopwood, D.M. Chisholm
Primary Institution: University of Dundee
Hypothesis
It was hypothesised that one may be able to visualise field changes around tumours as alterations in keratin intermediate filament protein expression.
Conclusion
The study found significant changes in keratin expression in normal oral mucosa from cancer patients, suggesting a potential marker for field change.
Supporting Evidence
- Changes in keratin expression were observed in clinically normal epithelium from oral cancer patients.
- 12 out of 34 biopsies showed substantial expression of keratins K8/K7 in the basal cells.
- Monitoring keratin expression may provide prognostic and diagnostic significance.
Takeaway
Doctors looked at tissue from mouth cancer patients and found changes in the proteins that help cells stick together, even in areas that looked normal.
Methodology
Standard immunohistochemical analysis using a panel of monoclonal anti-keratin antibodies was applied to fresh tissue sections.
Potential Biases
Potential bias due to the influence of smoking and alcohol habits on keratin expression.
Limitations
The study only covers a 3 year period and does not determine the clinical significance of the changes observed.
Participant Demographics
34 patients with oral cancer and 20 patients with no history of oral cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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