Autoantibodies in Sjogren's Syndrome
Author Information
Author(s): Boris Gilburd, Mahmoud Abu-Shakra, Yehuda Shoenfeld, Andrea Giordano, Elena Bartoloni Bocci, Francesco Delle Monache, Roberto Gerli
Primary Institution: Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University
Hypothesis
To evaluate the Athena Multi-Lyte ANA Test System for detecting antinuclear antibodies in patients with Sjogren's syndrome.
Conclusion
The AtheNa Multi-Lyte ANA Test System offers a sensitive and specific result for the detection of ANA and ENA antibodies in the sera of patients with Sjogren's syndrome.
Supporting Evidence
- ANA was found in 3% of sera from healthy subjects by the AtheNA system.
- A 99% concordance between the AtheNA and ELISA assays was found.
- Anti-SS/A and anti-SS/B were identified in 84% and 76% of the sera from patients with Sjogren's syndrome, respectively.
Takeaway
This study tested a new method to find specific antibodies in patients with Sjogren's syndrome, showing it works well.
Methodology
The study used a multiplex bead array assay to detect ANA and ENA antibodies in the sera of patients with Sjogren's syndrome and healthy subjects.
Participant Demographics
All participants were women with a mean age of 48.7 years.
Digital Object Identifier (DOI)
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