Oxidative Balance Indicators and Chronic Kidney Disease
Author Information
Author(s): Chen Xinyun, Shi Fangyu, Yu Wenhui, Gao Chang, Gou Shenju, Fu Ping
Primary Institution: West China Hospital, Sichuan University, Chengdu, China
Hypothesis
The study investigates the relationship between oxidative balance indicators and the risk of chronic kidney disease (CKD).
Conclusion
Higher levels of oxidative balance indicators, particularly the Oxidative Balance Score (OBS) and Pro-Oxidant-Antioxidant Balance (PAB), are associated with a reduced risk of CKD.
Supporting Evidence
- Higher OBS and PAB levels were significantly associated with a reduced risk of CKD.
- OBS demonstrated the strongest predictive ability for CKD risk among the indicators.
- TAC showed no significant association with CKD.
- Participants in higher quartiles of OBS had a significantly lower risk of CKD.
- ROC curve analysis indicated that OBS had a superior predictive ability for CKD risk.
Takeaway
This study found that eating healthy and balancing antioxidants can help lower the risk of kidney problems.
Methodology
A cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2018, employing logistic regression models.
Potential Biases
Potential reporting bias due to self-reported dietary and lifestyle data.
Limitations
The cross-sectional design limits causal inference, and reliance on self-reported data may introduce bias.
Participant Demographics
Participants included a diverse population from the NHANES surveys, with a mean age of 47.67 years and a gender distribution of 48.4% male.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 0.96–0.99
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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