Combining Antithrombin III and R-TPA for Treating DIC in Neonatal Pigs
Author Information
Author(s): Rachel Davis-Jackson, Hernan Correa, Ronald Horswell, Halina Sadowska-Krowicka, Kathleen McDonough, Chittaranjan Debata, Renee Gardner, Duna Penn
Primary Institution: Louisiana State University Health Sciences Center
Hypothesis
Replacement of both anticoagulants and fibrinolytics may improve survival and outcome better than either single agent or supportive care alone.
Conclusion
Combining AT, R-TPA, and supportive care may be more effective in treating DIC in neonatal pigs than using single therapies.
Supporting Evidence
- Combination therapy with AT and R-TPA significantly improved survival time compared to supportive care alone.
- R-TPA alone reduced macroscopic organ involvement compared to supportive care.
- AT alone increased AT levels significantly.
Takeaway
This study tested a new treatment for sick baby pigs that combines two medicines to help them survive a serious blood condition.
Methodology
Twenty-seven neonatal pigs were divided into four treatment groups and monitored for survival and organ involvement after inducing DIC with endotoxin.
Limitations
The small sample size limited the power to detect significant differences.
Participant Demographics
Neonatal pigs aged 7 to 14 days.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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