Review of WR-2721 and Glutathione as Chemoprotective Agents
Author Information
Author(s): Hospers G A P, Eisenhauer E A, Vries E G E de
Primary Institution: Division of Medical Oncology, Department of Internal Medicine, Groningen, The Netherlands
Hypothesis
Can WR-2721 and glutathione reduce the toxicity associated with radio- and chemotherapy?
Conclusion
WR-2721 and glutathione may help reduce certain toxicities from chemotherapy, but their exact roles as chemoprotectors are not fully understood.
Supporting Evidence
- WR-2721 has been registered for use in humans in many countries.
- GSH is a naturally occurring compound but is not registered as a chemoprotective agent.
- WR-2721 and GSH have shown to decrease cisplatin-induced nephrotoxicity.
- WR-2721 reduces radiation-induced toxicity.
Takeaway
This study looks at two compounds that might help protect patients from the bad side effects of cancer treatments. They found that one of the compounds, WR-2721, can help with some side effects, but more research is needed.
Methodology
The article reviews existing studies on WR-2721 and glutathione regarding their protective effects during chemotherapy and radiotherapy.
Limitations
The exact role of WR-2721 and glutathione as chemoprotectors is not yet completely clear.
Digital Object Identifier (DOI)
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