Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study
2011

Bone Health Supplement Study

Sample size: 158 publication Evidence: moderate

Author Information

Author(s): Michalek Joel E, Preuss Harry G, Croft Harry A, Keith Patti L, Keith Samuel C, Dapilmoto Monika, Perricone Nicholas V, Leckie Robert B, Kaats Gilbert R

Primary Institution: University of Texas Health Science Center at San Antonio

Hypothesis

Does a common bone health plan with two different supplements improve bone mineral density?

Conclusion

Both versions of the bone health supplement led to significant increases in bone mineral density, with the second version showing greater improvement.

Supporting Evidence

  • Both groups experienced a significant positive mean annualized percent change in bone mineral density compared to expectation.
  • AlgaeCal 2 showed a significantly greater increase in bone mineral density than AlgaeCal 1.
  • Increased compliance was associated with greater increases in bone mineral density in both groups.
  • No adverse effects were reported in either group.

Takeaway

This study looked at how two different supplements help bones get stronger. Both worked, but one worked better than the other.

Methodology

158 adults followed an open-label bone-health plan for six months, with two groups using different supplements.

Potential Biases

Potential volunteer bias due to the nature of recruitment.

Limitations

The study lacked a placebo-controlled arm and had unequal subject groups.

Participant Demographics

Adults aged 18-85, with a majority being female.

Statistical Information

P-Value

p = 0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1475-2891-10-32

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