Modulation of paclitaxel resistance by annexin IV in human cancer cell lines
2000
How annexin IV affects cancer drug resistance
publication
Author Information
Author(s): Han E Kyu-Ho, Tahir S K, Cherian S P, Collins N, Ng S-C
Primary Institution: Abbott Laboratories
Hypothesis
Does annexin IV contribute to paclitaxel resistance in cancer cells?
Conclusion
Annexin IV is involved in increasing resistance to paclitaxel in certain cancer cell lines.
Supporting Evidence
- Annexin IV was overexpressed in paclitaxel-resistant H460/T800 cells.
- Short-term treatment with paclitaxel induced annexin IV expression.
- Cells pretreated with paclitaxel became fivefold more resistant to the drug.
- Transfection of annexin IV cDNA increased paclitaxel resistance threefold.
Takeaway
This study found that a protein called annexin IV helps cancer cells resist a drug called paclitaxel, making the drug less effective.
Methodology
The study involved examining protein expression in paclitaxel-resistant cancer cells and testing the effects of annexin IV on drug resistance.
Digital Object Identifier (DOI)
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