Distribution of Nanoparticles in the See-through Medaka
Author Information
Author(s): Kashiwada Shosaku
Primary Institution: National Institute for Environmental Studies, Tsukuba, Japan
Hypothesis
The study investigates the distribution of water-suspended fluorescent nanoparticles in the eggs and bodies of see-through medaka (Oryzias latipes).
Conclusion
Nanoparticles can penetrate the blood-brain barrier and their bioavailability and toxicity depend on environmental factors and physicochemical properties.
Supporting Evidence
- Particles 39.4–42,000 nm in diameter were adsorbed to the chorion of medaka eggs and accumulated in the oil droplets.
- 474-nm particles had the highest bioavailability to eggs.
- Adult medaka accumulated 39.4-nm nanoparticles mainly in the gills and intestine when exposed to a 10-mg/L nanoparticle solution.
- Concentrations of nanoparticles in the blood of male and female medaka were 16.5 and 10.5 ng/mg blood protein, respectively.
Takeaway
This study shows that tiny particles can get into fish and even reach their brains, which could be harmful.
Methodology
The study used water-suspended fluorescent nanoparticles to observe their distribution in medaka eggs and bodies through various exposure designs.
Limitations
The study does not provide data on the threshold of toxicity in aquatic organisms and the environmental relevance of risks posed by nanomaterials.
Participant Demographics
The study involved see-through medaka (Oryzias latipes) from the National Institute for Environmental Studies, Japan.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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