Clerodendrum Infortunatum as a Potential Treatment for Alzheimer's Disease
Author Information
Author(s): Atef Fatma, Abdelkawy Mostafa A., Eltanany Basma M., Pont Laura, Fayez Ahmed M., Abdelhameed Mohamed F., Benavente Fernando, Younis Inas Y., Otify Asmaa M.
Primary Institution: Cairo University
Hypothesis
This study aims to identify the main bioactive metabolites in Clerodendrum infortunatum and investigate its potential in protecting against cognitive decline in rats with scopolamine-induced Alzheimer's disease.
Conclusion
The study demonstrates that Clerodendrum infortunatum has therapeutic potential in mitigating cognitive decline in Alzheimer's disease by improving cognitive function and normalizing neurotransmitter levels.
Supporting Evidence
- The extract improved cognitive function in scopolamine-induced AD rats.
- Treatment with C. infortunatum at 200 and 400 mg/kg restored neurotransmitter levels to normal.
- The study identified 79 metabolites in the plant extract.
- Clerodendrum infortunatum showed antioxidant and anti-inflammatory properties.
- Histopathological analysis confirmed the protective effects of the extract on neuronal health.
Takeaway
Researchers found that a plant called Clerodendrum infortunatum can help improve memory in rats that were made forgetful by a drug, suggesting it might help people with Alzheimer's disease.
Methodology
The study used LC-QTOF-MS/MS metabolomics to profile the methanol extract of Clerodendrum infortunatum and assessed its anti-Alzheimer potential in scopolamine-induced AD rats through various biochemical and behavioral tests.
Limitations
Further studies are needed to isolate and evaluate individual bioactive metabolites or enriched fractions.
Participant Demographics
Male adult Wistar albino rats (200–250 g)
Statistical Information
P-Value
0.18
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website